Klaus Seuwen, Ph.D.
senior drug discovery leader | GPCR expert
Klaus has more than 35 years of drug discovery experience in academia and pharmaceutical industry. He earned a PhD in cell biology and biophysics at the University of Konstanz, Germany. Following an academic career at the University of Nice, France, and San Francisco, USA, he joined the Novartis Institutes for Biomedical Research in Basel, Switzerland, as a group leader and Research Director. At Novartis, he notably led a research platform aimed at understanding the physiology of newly discovered G protein-coupled receptors (GPCRs). His team’s efforts led to the discovery of pH-sensing receptors and receptors for oxysterols and peptide chemotactic agents. Klaus’ scientific interests further include the control of cell proliferation and differentiation by hormones and growth factors, stem cell biology, immunology.
Email Klaus: k.seuwen@steerbio.com
Selected publications:
Ludwig, M.-G. et al., Proton-sensing G protein-coupled receptors. Nature 425: 93-98, 2003.
Jacoby, E., Bouhelal, R., Gerspacher, M., Seuwen, K. The 7 TM G-protein-coupled receptor target family. Chem Med Chem. 8: 761-782, 2006.
Mullershausen F et al., Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors. Nat Chem Biol. 5:428-34, 2009.
Hannedouche S et al., Oxysterols direct immune cell migration via EBI2. Nature. 475:524-7, 2011.
Bassilana F et al., Target identification for a Hedgehog pathway inhibitor reveals the receptor GPR39. Nat Chem Biol. 10:343-9, 2014.
Kumar NN et al., Regulation of breathing by CO₂ requires the proton-activated receptor GPR4 in retrotrapezoid nucleus neurons. Science 348:1255-60, 2015.
Suply T et al., A natural ligand for the orphan receptor GPR15 modulates lymphocyte recruitment to epithelia. Sci Signal. 496: 2-11, 2017
Bridges JP et al., Regulation of pulmonary surfactant by the adhesion GPCR GPR116/ADGRF5 requires a tethered agonist-mediated activation mechanism. Elife. 11:e69061, 2022
Hausmann M et al., Role of pH-sensing receptors in colitis. Pflugers Arch. 476(4): 611-622, 2024
